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This review will discuss the recent progress made in the development of inhibitors for the Rho GTPases and their application in the treatment of disease. Advances in this exciting field have been made through the introduction of both chemical inhibitors and antagonist monoclonal antibodies, and the isolation of natural Rho GTPase inhibitors. New insights into the roles of Rho GTPases in the function of non-malignant cells have highlighted a therapeutic window for the treatment of disorders arising from aberrant Rho GTPase function. Agents targeting Cdc42 and Rac have now been developed, and have shown promise both in the treatment of tumours and as chemopreventive agents. The next generation of drugs is being developed based on optimising existing compounds. The caveats to development and approval of such agents are reviewed here, as is the potential to reverse resistance to small molecule inhibitors.// *** WARNING: this file was generated by the Pulumi Terraform Bridge (tfgen) Tool. ***
// *** Do not edit by hand unless you’re certain you know what you are doing! ***
using System;
using System.Collections.Generic;
using System.Collections.Immutable;
using System.Threading.Tasks;
using Pulumi.Serialization;
namespace Pulumi.Aws.WafV2.Outputs
{
[OutputType]
public sealed class WebAclRuleStatementOrStatementStatementAndStatementStatementNotStatementStatementGeoMatchStatement
{
///
/// The area surrounding the domain name, defined by the domain’s geographic location. Valid values for GeographicalMatchPattern must contain a geographic location type. If the domain name does not have a geographic location, you should omit this parameter. Some domain names cannot be matched by a location pattern even when the domain contains a geographic location. For example,.com or.uk domains cannot be matched by a location pattern because they do
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